Lurasidona: Dez Anos de Utilização no Tratamento da Depressão Bipolar em Adultos
DOI:
https://doi.org/10.51338/rppsm.2021.v7.i2.199Palavras-chave:
Adultos, Antipsicóticos/uso terapêutico, Cloridrato de Lurasidona/uso terapêutico, Perturbação Bipolar/tratamento farmacológicoResumo
A lurasidona é um antipsicótico atípico, aprovado em 2010 no Canadá e Estados Unidos da América para o tratamento de doentes com o diagnóstico de esquizofrenia ou doença bipolar tipo I. Em 2014 obteve autorização de comercialização na União Europeia (UE), para o tratamento de doentes com 13 anos ou mais, com o diagnóstico de esquizofrenia. É um antipsicótico com estrutura derivada de benzisotiazol, com um perfil de ligação singular, que faz deste um candidato a antidepressivo com pouco impacto metabólico. Em doentes com diagnóstico de doença bipolar, os episódios depressivos tendem a estar presentes a maioria do tempo e a ser difíceis de tratar, como revelam vários estudos que indicam que mais de três quartos de doentes com depressão bipolar experimentam pelo menos dois fármacos e mais de um terço, três ou mais. Em linhas orientadoras de tratamento internacionais, as indicações de primeira linha no tratamento de episódios depressivos de doença bipolar são variadas, sendo a lurasidona considerada uma opção. Considerando a dificuldade na prática clínica em tratar os episódios depressivos na doença bipolar, a autorização de comercialização na UE exclusiva para utilização em esquizofrenia e a expectável disponibilidade do fármaco em Portugal no decurso do ano 2021, pretendemos realizar uma revisão de literatura com enfoque na eficácia e vantagens da utilização de lurasidona em episódios depressivos de doença bipolar e discutir a utilidade da sua aprovação como alternativa de tratamento.
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