Palmitato de Paliperidona num Adulto com Síndrome de Asperger
DOI:
https://doi.org/10.51338/rppsm.2020.v6.i2.127Palavras-chave:
Adulto, Antipsicóticos, Síndrome de Asperger, Palmitato de Paliperidona, PirimidinasResumo
A síndrome de Asperger éuma perturbação caraterizada pelo compromisso da interação social e um padrão de comportamentos estereotipados. Estes incluem comportamentos repetitivos, irritabilidade, agressividade, hiperatividade e desatenção. O tratamento dos sintomas comportamentais constitui um desafio, com escassos estudos acerca da eficácia das diferentes abordagens terapêuticas. Este artigo é a primeira descrição do uso bem‑sucedido de palmitato de paliperidona mensal no tratamento de sintomas comportamentais num adulto com síndrome de Asperger.
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Referências
The International Statistical Classification of Diseases and Related Health Problems. Tenth Revision. Geneva: World Health Organization; 1992.
Doyle C, McDougle, C. Pharmacologic treatments for the behavioural symptoms associated with autism spectrum disorders across the lifespan. Dialogues Clin Neurosci. 2012;14:263‑79.
Lecavalier L. Behavioral and emotional problems in young people with pervasive developmental disorders: relative prevalence, effects of subject characteristics, and empirical classification. J Autism Dev Disord. 2006;36:1101‑14. doi: 10.1007/s10803‑006‑0147‑5.
Mirkovic B, Gérardin P. Asperger’s syndrome: What to consider?. L’Encéphale. 2019;45:169‑74. doi: 10.1016/j.encep.2018.11.005.
LeClerc S, Easley D. Pharmacological therapies for autism spectrum disorder: a review. P T. 2015;40:389‑97.
McDougle CJ, Holmes JP, Carlson DC, Pelton GH, Cohen DJ, Price LH. A double‑blind, placebo‑controlled study of risperidone in adults with autistic disorder and other pervasive developmental disorders. Arch Gen Psychiatry. 1998;55:633‑41. doi: 10.1001/archpsyc.55.7.633.
Stigler KA, Erickson CA, Mullett JE, Posey DJ, McDougle CJ. Paliperidone for irritability in autistic disorder. J Child Adolesc Psychopharmacol. 2010;20:75‑8. doi: 10.1007/s00213‑012‑2711‑3.
Kowalski JL, Wink LK, Blankenship K, Habenicht CD, Erickson CA, Stigler KA, et al. Paliperidone palmitate in a child with autistic disorder. J Child Adolesc Psychopharmacol. 2011;21:491‑3. doi: 10.1089/cap.2011.0035.
Stigler KA, Mullett JE, Erickson CA, Posey DJ, McDougle CJ. Paliperidone for irritability in adolescents and young adults with autistic disorder. Psychopharmacology. 2012;223:237‑45. doi: 10.1007/s00213‑012‑2711‑3.
Stigler KA, Mullett JE, Erickson CA, Posey DJ, McDougle CJ. Paliperidone for irritability in adolescents and young adults with autistic disorder. Psychopharmacology. 2012;223:237‑45.
European Medicines Agency, Committee for Medicinal Products for Human Use. Summary of opinion (initial authorization) for Xeplion (paliperidone palmitate). [cited 2020 May 4]. Available from: https://www.ema.europa.eu/en/documents/smop‑initial/chmp‑summary‑positive‑opinion‑xeplion_en.pdf.
Domingues L, Cruz E. Adaptação Cultural e Contributo para a Validação da Escala
Patient Global Impression of Change. IfisiOnline. 2011;2:31‑7.
Stahl SM. Stahl’s essential psychopharmacology: Neuroscientific basis and practical applications. 4th ed. New York: Cambridge University Press; 2013.
Rado J, Dowd SM, Janicak PG. Paliperidone ER: Reformulated antipsychotic for schizophrenia Tx. Curr Psychiatry. 2007;6:75‑82.
Leucht S, Samara M, Heres S, Patel MX, Woods SW, Davis JM. Dose equivalents for second‑generation antipsychotics: the minimum effective dose method. Schizophr Bull. 2014;40:314‑26. doi:10.1093/schbul/sbu001
McEvoy JP, Byerly M, Hamer RM, Dominik R, Swartz MS, Rosenheck RA, et al. Effectiveness of paliperidone palmitate vs haloperidol decanoate for maintenance treatment of schizophrenia: a randomized clinical trial [published correction appears in JAMA. 2014;312:1473]. JAMA. 2014;311:1978‑87. doi:10.1001/jama.2014.4310